Review: ODT’s drug containing Spironolactone

  • Shalini Sharma Department of Pharmaceutics, Himachal Institute of Pharmacy Paonta Sahib, (H.P), India.
  • Ujjwal Nautiyal Department of Pharmaceutics, Himachal Institute of Pharmacy Paonta Sahib, (H.P), India.
Keywords: Orally disintegration tablets, Spironolactone, Superdisintegrants, Enhanced bioavailability.

Abstract

Orally disintegrating tablets (ODTs) have emerged as one of the popular and widely accepted dosage forms, especially for the pediatric and geriatric patients. To obviate the problem of dysphagia and to improve patient compliance, ODTs have gained considerable attention as preferred alternatives to conventional tablet and capsule formulations   In the present study, an attempt has been made to prepare orally disintegrating tablet of the drug Spironolactone using superdisintegrants crosspovidone, crosscarmellose sodium and sodium starch glycolate by direct compression technique. Various scientific techniques including freeze drying, moulding, spray drying, sublimation, direct compression, cotton candy process, mass extrusion, melt granulation etc. have been employed for the development of ODTs. The prepared tablets were evaluated for pre and post compression parameters i.e. angle of repose, car’s index, hausner’s ratio, hardness, friability, wetting time, weight variation, in vitro disintegration and in vitro dissolution study.

Published
2016-03-31