International Journal of Recent Advances in science and technology https://ijrast.com/index.php/ijrast International Journal of Recent Advances in science and technology (IJRAST) en-US International Journal of Recent Advances in science and technology Phytochemical Screening and Anti-inflammatory activity of Murraya Koenigii & Ficus Lacor roots in Carrageenan, Histamine and Serotonin induced paw edema in albino Wistar rats https://ijrast.com/index.php/ijrast/article/view/54 <p>Objective: To perform the Phytochemical Screening &amp; Anti-inflammatory activity of Murraya Koenigii &amp; Ficus Lacor roots in Albino Wistar rats.</p> <p>Methods: The different Pharmacognostical parameters were evaluated as per standard procedure. The crude drug was evaluated for organoleptic properties shape, size, color, odor, taste. Preliminary Phytochemical Screening was carried out &amp; finally Anti-inflammatory activity was evaluated by adopting different methods.</p> <p>Results: The extracts showed a marked Anti-inflammatory effect. The FLET fraction from Ficus lacor aerial roots showed maximum inhibition (75%) of Carrageenan induced edema (Table 3.12B), followed by FLPE and MKCF from Murraya koenigii roots (74 % and 70% approx) (p &lt;0.001 for all). The inhibition of inflammation was comparable for all the fractions for any change in extent &amp; percentage of inhibition at 30 min, 1hr, 2hr and 3hr. The anti-inflammatory effect induced via indomethacin gradually increased and reached at higher level (80.8%) after 3 hrs. It was maintained up to six hours. For, MKPE the inhibition was observed to be maximum at the end of 2 hrs and then tapered. MKEA, FLEA and FLCF showed minimum response that was constant throughout and insignificant. MKPE was slightly significant (55.1 %, p&lt;0.05) which was more effective.</p> <p>Conclusion: The results of the study indicate that the extract of Murraya koenigii roots and Ficus lacor possesses strong Anti-inflammatory activity. This study also describes therapeutic effect of Murraya koenigii roots and Ficus lacor aerial roots in inflammation and arthritis which will give a new direction for the future scientific research.</p> Kapil Dev Pandey Yogendra Singh Naresh Khatri Narendra Singh Copyright (c) 2020 International Journal of Recent Advances in science and technology 2020-08-21 2020-08-21 6 4 1 12